JECFA Toolbox for Veterinary Drug Residues Risk Assessment

Section 1: The JECFA risk assessment process
13/05/2024

This guidance document provides a high-level summary of the entire JECFA veterinary drug residue risk assessment process, with each step described in greater detail in subsequent sections.

Veterinary drug residues from animal-derived food products may pose risks to human health. To perform a drug residue risk assessment, we must first characterize the risk by evaluating the hazard and assessing exposure.

Consult the guidance document for a brief description of the relevant data necessary for the evaluation process, followed by the key outcomes and relevant JECFA experts responsible along each step of the JECFA risk assessment process:

 

  • Hazard assessment: Derivation of health-based guidance values (HBGVs) such as acceptable daily intake (ADI) and acute reference dose (ARfD);
  • Residue assessment: Total residue (TR) and marker residue (MR) depletion in edible tissues;
  • Exposure assessment: Use of the global estimated chronic or acute dietary intake; and
  • How maximum residue limits (MRLs) are derived as the final step of the JECFA risk assessment process.