Section 4.1. Estimating total residues for use in exposure calculations
13/05/2024
This guidance document explains how data from radiolabelled and marker residue studies are combined to provide more realistic estimates of total residue levels for use in JECFA’s dietary exposure assessment.
By this point, you will understand the roles of both the total residue and marker residue depletion studies.
Consult the guidance document to:
- review how the M:T ratios are calculated in edible tissues at any time point after drug administration; and
- see how total residue estimates are calculated based on the marker residue depletion and M:T data.