Regional commissions meet every two years and benefit from a specific FAO budget allocation. They are serviced by a Technical Secretary responsible for all operations.

• Agriculture and Land and Water Use Commission  ALAWUC provides a forum through which Member Countries can exchange information and experience on important issues and concerns relating to agriculture, land and water use. ALAWUC promotes regional and sub-regional cooperation to overcome problems in water resources management, sustainable land use and conservation of the land and water resources in the Region.
• Regional Commission for Fisheries (RECOFI) The mandate of RECOFI is to promote the development, conservation, rational management and best utilization of living marine resources, as well as the sustainable development of aquaculture in the Gulf and the Sea of Oman.
• Near East Forestry and Range Commission (NEFRC) The mandate of NEFRC is to provide a policy and technical forum where  the countries of the Near East can discuss and address forest issues on a regional basis. It advises on the formulation of forest policy and reviews and coordinates policy implementation at the regional level.
• The FAO Commission for Controlling the Desert Locust in the Central Region (CRC) The primary mandate of CRC is to promote national, regional and international cooperation and coordination within the region and to pay particular attention to capacity development related to Desert Locust survey and control.