A continuación, se enumeran todas las referencias citadas en los documentos de orientación de la Caja de herramientas del JECFA, seguidas de recursos disponibles para lectura adicional.

Referencias

CAC (Codex Alimentarius Commission). 1999. CAC/GL 30-1999: Principles and guidelines for the conduct of microbiological risk assessment (Amendments 2012, 2014). Codex Alimentarius Commission.

Dick, M. 2019. Total residue depletion and metabolism study of 14C-Halquinol after oral administration to growing pigs at 24 mg/kg per day for 5 consecutive days. Study Number ELA1800653. Sponsor submitted.

FAO & WHO. 2016. Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives - 81st Meeting. FAO JECFA Monograph 18.

FAO & WHO. 2018. FAO/WHO Chronic individual food consumption database – Summary statistics.

FAO & WHO. 2020. Residue evaluation of certain veterinary drugs. Joint FAO/WHO Expert Committee on Food Additives – 88th Meeting 2019. Joint FAO/WHO Expert Committee on Food Additives (JECFA) Monographs No. 24. Rome.

FAO & WHO. 2021. Maximum Residue Limits (MRLs) and Risk Management Recommendations (RMRs) for Residues of Veterinary Drugs in Foods. CX/MRL 2-2021. Codex Alimentarius International Food Standards.

Hall, C. 2017. Marker residue depletion following oral administration of Quixalud inFeed (Halquinol 700 ppm) to swine for 10 consecutive days. Study Number NAH-16- 067. Sponsor submitted.

Piñeiro, S.A., Cerniglia, C.E. 2021. Antimicrobial drug residues in animal-derived foods: Potential impact on the human intestinal microbiome. J vet Pharmacol Ther; 44:215-222.

Salleras, L., Domínguez, A., Mata, E., Taberber, J.L., Moro, I. & Salvà, P. 1995. Epidemiologic study of an outbreak of clenbuterol poisoning in Catalonia, Spain. Public Health Rep, 110(3): 338-42. PMID: 7610227.

VICH (International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products). 2004a. Studies to evaluate the safety of residues of veterinary drugs in human food: Reproduction testing. VICH GL22 (Safety: Reproduction). June 2001 - Implemented on 1 August 2002 - Revision 1 of May 2004.

VICH. 2004b. Studies to evaluate the safety of residues of veterinary drugs in human food: Developmental toxicity testing. VICH GL32 (Safety: Developmental Toxicity). October 2002 - For implementation in October 2003 (Except EU: later date) - Revision 1 of May 2004.

VICH. 2004c. Studies to evaluate the safety of residues of veterinary drug in human food: carcinogenicity testing (Revision at Step 9). VICH GL28 (Safety: Carcinogenicity) October 2004 - Implemented in March 2006.

VICH. 2011. Studies to evaluate the metabolism and residue kinetics of veterinary drugs in food-producing animals: Metabolism study to determine the quantity and identify the nature of residues. VICH GL46 (MRK) - February 2011 - Implemented in February 2012.

VICH. 2014. Studies to evaluate the safety of residues of veterinary drugs in human food: Genotoxicity Testing. VICH GL23(R) (Safety: Genotoxicity) October 2014 - Implemented in October 2015.

VICH. 2015a. Studies to evaluate the metabolism and residue kinetics of veterinary drugs in food-producing animals: Marker residue depletion studies to establish product withdrawal periods. VICH GL48(R) (MRK) - February 2015 - Implemented in January 2016.

VICH. 2015b. Studies to evaluate the metabolism and residue kinetics of veterinary drugs in food-producing animals: Validation of analytical methods used in residue depletion studies. VICH GL49(R) (MRK) - January 2015 - Implemented in January 2016.

VICH. 2016. Studies to Evaluate the Safety of Residues of Veterinary Drugs in Human Food: General Approach to Establish an Acute Reference Dose (ARfD). VICH GL54 (Safety) November 2016 - For implementation by November 2017.

WHO & FAO. 2009. Principles and methods for the risk assessment of chemicals in food. Environmental Health Criteria 240. Geneva, World Health Organization.  

Additional reading

VICH. Guidelines - Toxicology

VICH. Guidelines - Antimicrobial safety

VICH. Guidelines - Metabolism and residue kinetics

Codex Committee on Residues of Veterinary Drugs in Foods (CCRVDF). Glossary of terms and definitions (Residues of Veterinary Drugs in Foods)