The implementation of the Swiss National Plan of Action for the Conservation and Sustainable Use of Plant Genetic Resources for Food and Agriculture (NPA-PGRFA) started in 1999. The Ordinance on Conservation and Sustainable Use of PGRFA referring to the NPA-PGRFA entered into force in 2015. It provides a stronger legal framework for the measures for conservation of PGRFA and regulates the management of the national gene bank of PGRFA in Switzerland. NPA-PGRFA strategies and guidelines are defined and implemented based on a multi-stakeholder approach, together with a wide range of private and public institutions. Farmers and farmers’ organizations can participate and profit in many ways from the NPA-PGRFA through promoted activities such as the maintenance and marketing of landraces/farmers' varieties; participatory plant breeding/participatory varietal selection; seed-exchange networks; facilitated access to information on plant genetic diversity so as capacity building. Three hundred projects have been completed so far, with 100 on-going projects in collaboration with regional and national organizations. These projects are listed in the national genebank. Key measures for the sustainable use of PGRFA are the characterization and evaluation of plant genetic resources as well as ensuring high phytosanitary standards for propagation material and promoting PGRFA for niche production.